P-232 The predictive factors for identifying gastric cancer in patients with gastric ‘indefinite for neoplasia’ lesions

Gastric ‘indefinite for neoplasia’(IFN) on endoscopic biopsy is a borderline lesion that difficult to diagnosis as either benign or malignant. However, guidelines management of this remain unclear. Here, we aimed evaluate the clinical course patients with IFN and determine predictive factors progression gastric cancer. We retrospectively included 121 cases proven initial histology forceps biopsy. Of cases, submucosal dissection(ESD) (36/121, 29.8%), operation (2/121, 1.7%) follow-up (83/121, 68.6%) were performed. The data histologic features lesions analyzed neoplasms. After diagnostic modalities, final pathologic diagnoses cancer (38/121, 31.4 %), dysplasia (14/121, 11.6 non-neoplasm (69/121, 57.0 %). In univariate analysis, size 15 mm greater [odds ratio (OR) 3.10, 95 % confidence interval (CI) 1.17–8.12, p=0.02], mucosal unevenness (OR 4.61, CI 1.16–18.38, p=0.03), ulceration 4.14, 1.60–10.76, p=0.004) spontaneous bleeding 4.06, 1.16–14.21, p=0.03) risk neoplasm. multivariate 4.29, 1.35–13.58, p=0.013), 3.79, 1.37–10.51, p=0.01) 4.35, 1.12–8.52, independent Considering neoplastic IFN, procedures such ESD may be more useful definite treatment, particularly in accompanied by factors, unevenness, bleeding.